IMR Press / JIN / Volume 21 / Issue 1 / DOI: 10.31083/j.jin2101014
Open Access Review
Research progress of natural products for the treatment of ischemic stroke
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1 School of Pharmacy, Shandong University of Traditional Chinese Medicine, 250355 Ji'nan, Shandong, China
2 College of Foreign Languages, Shandong University of Traditional Chinese medicine, 250355 Ji'nan, Shandong, China
3 The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, 510006 Guangzhou, Guangdong, China
4 Innovation Research Institute of Chinese Medicine, Shandong University of Traditional Chinese medicine, 250355 Ji'nan, Shandong, China
5 The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 310030 Hangzhou, Zhejiang, China
6 Shandong Institute for Food and Drug Control, 250101 Ji'nan, Shandong, China
*Correspondence: (Peng Sun); (Yu Feng); (Jun Li)
These authors contributed equally.
J. Integr. Neurosci. 2022, 21(1), 14;
Submitted: 31 May 2021 | Revised: 2 July 2021 | Accepted: 22 September 2021 | Published: 28 January 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Stroke is a leading cause of death and disability world-widely. The incidence rate of stroke has been increasing due to the aging population and lifestyle changes. At present, the only drug approved by the US Food and Drug Administration (FDA) for the treatment of ischemic stroke is tissue plasminogen activator (t-PA), but its clinical application is greatly limited because of its narrow time window and bleeding risk. Natural products have a long history of being used in traditional medicine with good safety, making them an important resource for the development of new drugs. Indeed, some natural products can target a variety of pathophysiological processes related to stroke, including oxidative stress, inflammation and neuronal apoptosis. Therefore, the development of high-efficiency, low-toxicity, safe and cheap active substances from natural products is of great significance for improving the treatment alternatives of patients with stroke. This article reviews the neuroprotective effects of 33 natural compounds by searching recent related literature. Among them, puerarin, pinocembrin, quercetin, epigallocatechin-3-gallate (EGCG), and resveratrol have great potential in the clinical treatment of ischemic stroke. This review will provide a powerful reference for screening natural compounds with potential clinical application value in ischemic stroke or synthesizing new neuroprotective agents with natural compounds as lead compounds.

Natural products
Ischemic stroke
Fig. 1.
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