†These authors contributed equally.
According to the recent findings, autophagy modulation is being a potential
therapeutic target in the management of ischemic stroke in a pre-clinical
setting. However, the pros and cons of autophagic response strongly depend on the
activation time of autophagy after injury. In this systematic review, we aimed to
explore the impacts of pharmacological modulation of autophagy on infarct size in
experimental ischemic stroke models. Based on our preliminary search, 3551
publications were identified. Of twenty-nine publications that met the inclusion
criteria, twenty studies reported infarct volume reduction by percentage (%)
with no evidence of any publication bias while nine studies reported by mm