Hypobaric hypoxia is a stressful condition known to decrease fertility both in
humans and animals. However, the mechanism by which the
hypothalamus-pituitary-gonad axis is altered remains unknown. The aim of the
present study was to analyze the effects of chronic intermittent and continuous
exposure to hypoxia on hypothalamic-pituitary-gonadal axis regulation in male
rats. Thirty adult male Wistar rats were assigned to one of the following three
groups: control group; chronic intermittent hypoxia: subjected to 600 mbar for 18
h/d five days a week; and chronic continuous hypoxia: subjected to 600 mbar for 23.5
hours/day seven days a week, for 30 days. Plasma luteinizing hormone and
testosterone concentration, hypothalamic GnRh, Kiss1 and Rfrp3
mRNA levels and PGE
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Altered production of reproductive neuropeptides in rats subjected to chronic intermittent hypoxia
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1
Cátedra de Fisiología, Facultad de Odontología, Universidad de Buenos Aires, 1122 Buenos Aires, Argentina
2
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Oral Physiology Laboratory, 1122 Buenos Aires, Argentina
*Correspondence: antonela.terrizzi@odontologia.uba.ar (Antonela Romina Terrizzi)
J. Integr. Neurosci. 2021, 20(3), 651–657;
https://doi.org/10.31083/j.jin2003069
Submitted: 15 April 2021 | Revised: 30 April 2021 | Accepted: 28 May 2021 | Published: 30 September 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Hypoxia
Hypothalamic peptides
Hypothalamic-pituitary-gonadal axis
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