IMR Press / JIN / Volume 20 / Issue 2 / DOI: 10.31083/j.jin2002051
Open Access Perspective
Hypersexuality in neurological diseases: do we see only the tip of the iceberg?
Show Less
1 IRCCS Centro Neurolesi “Bonino-Pulejo” S.S. 113, Contrada Casazza, 98124 Messina, Italy
2 Department of Biomedical and Biotechnological Science, University of Catania, Via S. Sofia, 98, 95123 Catania CT., Italy
3 tudio di Riabilitazione Nutrizionale e Cognitiva, Via Sant’Agostino, 14, 98121, Messina, Italy
4 OU Policlinico G. Martino, Via Consolare Valeria, 1, 98124 Messina, Italy
*Correspondence: (Rocco Salvatore Calabrò)
J. Integr. Neurosci. 2021, 20(2), 477–487;
Submitted: 7 March 2021 | Revised: 2 April 2021 | Accepted: 19 April 2021 | Published: 30 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

The purpose of this commentary is to investigate the pathophysiological mechanisms underlying hypersexuality and its manifestation in neurological diseases through a meta-analysis. Studies were identified by searching on PubMed, Web of Science and Cochrane databases. All results of each database between 2014 and 2020 were evaluated for possible inclusion. After an accurate revision of complete manuscripts, forty articles satisfied the inclusion/exclusion criteria. Data from our meta-analysis indicated hypersexuality to be a frequent sexual disorder in patients with neurological disorders, especially neurodegenerative ones. Hypersexuality could negatively affect a patient’s management and outcomes. This commentary discusses studies that are often incomplete for evaluation measures or sample selection. In our opinion, it is necessary to consider hypersexuality with particular attention, so more extensive sample studies are needed to find the most appropriate treatment to improve the quality of life for both the patient and the caregiver.

Sexual addiction
Neurological disorder
Fig. 1.
Back to top