IMR Press / JIN / Volume 20 / Issue 2 / DOI: 10.31083/j.jin2002035
Open Access Short Communication
Combining reverse end-to-side neurorrhaphy with rapamycin treatment on chronically denervated muscle in rats
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1 Department of Orthopedics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China
2 Department of Orthopedics, Peking University Third Hospital, Beijing Key Laboratory of Spinal Disease, 100044 Beijing, China
*Correspondence: (Qingtian Li)
These authors contributed equally.
J. Integr. Neurosci. 2021, 20(2), 359–366;
Submitted: 4 February 2021 | Revised: 4 March 2021 | Accepted: 7 April 2021 | Published: 30 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

This preliminary research determines whether a combination of reverse end-to-side neurorrhaphy and rapamycin treatment achieves a better functional outcome than a single application after prolonged peripheral nerve injury. We found that the tibial nerve function of the reverse end-to-side + rapamycin group recovered better, with a higher tibial function index value, higher amplitude recovery rate, and shorter latency delay rate (P < 0.05). The reverse end-to-side + rapamycin group better protected the gastrocnemius muscle with more forceful contractility, tetanic tension, and a higher myofibril cross-sectional area (P < 0.05). Combining reverse end-to-side neurorrhaphy with rapamycin treatment is a practical approach to promoting the recovery of chronically denervated muscle atrophy after peripheral nerve injury.

Peripheral nerve injury
Muscle denervation
Nerve regeneration
Reverse end-to-side neurorrhaphy
Fig. 1.
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