Previous studies have confirmed the sex difference of gray matter asymmetry in
typically developing controls and the abnormal gray matter asymmetry in autism
spectrum disorders. However, whether and how sex differences of gray matter
asymmetry exist in autism spectrum disorders remains studied. This paper analyzes
the above issues and explores correlations between gray matter asymmetry and
autistic symptoms. Data from 72 children (36 males and 36 females) with autism
spectrum disorders and 72 typically developing-controls (36 males and 36 females)
between 8 and 14 years were included and obtained from the autism brain imaging
data exchange repository (autism brain imaging data exchange I and autism brain
imaging data exchange II). The voxel-based morphometry approach was used to
assess gray matter asymmetry in T1-weighted brain data, and gray matter asymmetry
was quantified as asymmetry index. A 2
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Original Research
Sex differences in structural brain asymmetry of children with autism spectrum disorders
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1
Department of Radiology, Zhongnan Hospital of Wuhan University, 430000 Wuhan, Hubei Province, China
2
Department of Pediatrics, Zhongnan Hospital of Wuhan University, 430000 Wuhan, Hubei Province, China
*Correspondence: xuhaibo@whu.edu.cn (Haibo Xu)
J. Integr. Neurosci. 2021, 20(2), 331–340;
https://doi.org/10.31083/j.jin2002032
Submitted: 24 December 2020 | Revised: 20 February 2021 | Accepted: 28 April 2021 | Published: 30 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Autism spectrum disorders
Gray matter asymmetry
Asymmetry index
Sex factors
Brain imaging
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