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Perspective
The emerging role of non-coding RNAs from extracellular vesicles in Alzheimer’s disease
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1
Department of Clinical Laboratory, Shenzhen Baoan Hospital, Southern Medical University, 518000 Shenzhen, P. R. China
2
Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, P. R. China
3
Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, P. R. China
*Correspondence: wangxiong@tjh.tjmu.edu.cn (Xiong Wang); 2016tj0255@hust.edu.cn (Yu Hu)
†These authors contributed equally.
†These authors contributed equally.
J. Integr. Neurosci. 2021, 20(1), 239–245;
https://doi.org/10.31083/j.jin.2021.01.360
Submitted: 31 October 2020 | Revised: 4 December 2020 | Accepted: 12 January 2021 | Published: 30 March 2021
Copyright: © 2021 The Authors. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Alzheimer’s disease is an age-dependent neurodegenerative disease. Recently, different non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, have been found to contribute to Alzheimer’s disease’s pathogenesis. Extracellular vehicles could be enriched in ncRNAs and in their role in mediating intercellular communication. Signatures of extracellular vesicular ncRNAs have shown them to be a potential biomarker in Alzheimer’s disease. This perspective discusses the potential role of extracellular vehicle ncRNAs in Alzheimer’s disease, providing a theoretical basis for extracellular vesicular ncRNAs in Alzheimer’s disease, from pathogenesis to diagnosis and treatment.
Keywords
Alzheimer's disease
Non-coding RNA
Extracellular vesicle
Exosome
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