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IMR Press / JIN / Volume 20 / Issue 1 / DOI: 10.31083/j.jin.2021.01.228
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Prognostic value of serum pentraxin 3 for intracerebral hemorrhage mortality
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1 Department of Neurosurgery, Xi’an International Medical Center Hospital, 710100 Xi’an, P. R. China
2 Clinical Laboratory Center, Xi’an Fourth Hospital, 710104 Xi’an, P. R. China
3 Department of Neurosurgery, The First Affiliated Hospital of Xi’an Medical University, 710077 Xi’an, P. R. China
*Correspondence: haopuheng@126.com (Pu-Heng Hao)
J. Integr. Neurosci. 2021, 20(1), 137–142; https://doi.org/10.31083/j.jin.2021.01.228
Submitted: 28 July 2020 | Revised: 29 November 2020 | Accepted: 4 December 2020 | Published: 30 March 2021
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract

Pentraxin 3 is considered an important inflammatory marker is known to increase in patients with ischemic stroke, but the relationship between pentraxin 3 and intracerebral hemorrhage mortality is unclear. The purpose of this study is to investigate the level of pentraxin 3 in serum and its impact on prognosis in 307 patients with intracerebral hemorrhage. During the 5-year follow-up, the mortality rate of patients with intracerebral hemorrhage was 22.5%. The serum pentraxin 3 level of the brain-dead patients was higher than that of the control group (P $<$ 0.05). Logistic regression analysis indicated a high correlation between the pentraxin 3 level and the mortality rate 95% (hazard ratio: 3.671; confidence interval: 1.558-4.297). The receiver operating characteristic curve showed that pentraxin 3 (Area Under Curve = 0.801) had a higher diagnostic value than C-reactive protein (Area Under Curve = 0.701). The pentraxin 3 level increased significantly after intracerebral hemorrhage and has an important predictive value for a prognosis for intracerebral hemorrhage mortality.

Keywords
Intracerebral hemorrhage
Serum pentraxin 3
Neuroinflammation
Mortality
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