IMR Press / JIN / Volume 19 / Issue 4 / DOI: 10.31083/j.jin.2020.04.370
Open Access Mini-Review
Can we improve the prediction of complications and outcome in aneurysmal subarachnoid hemorrhage? The clinical implications of serum proteomics
Show Less
1 Department of Neurosurgery, American University of Beirut Medical Center, Beirut, Lebanon
2 Faculty of Medicine, Lebanese University, Beirut, Lebanon
*Correspondence: (Tarek Sunna)
J. Integr. Neurosci. 2020, 19(4), 711–717;
Submitted: 3 November 2020 | Revised: 29 November 2020 | Accepted: 14 December 2020 | Published: 30 December 2020
Copyright: © 2020 Bsat et al. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Aneurysmal subarachnoid hemorrhage is a devastating condition, often leading to a debilitating outcome. Delayed ischemic neurological deficits are considered the feared sequelae. Proteomics is a large-scale study of proteins incorporating structural and functional properties in complex biological fluids. Analysis of proteomes has led to identifying relevant complex proteins related to specific pathophysiological processes reflecting the severity and extent of diseases. Proteomics has evolved in the past few years; more biomarkers are deemed clinically relevant to diagnose, monitor, and define prognosis in patients with aneurysmal subarachnoid hemorrhage. Despite the absence of candidate biomarkers in the clinical routine, many have shown promising results. The complexity of proteins implicated in aneurysmal subarachnoid hemorrhage rendered these biomarkers’ clinical use paved with various pitfalls and technical difficulties, especially when data about the perfect timing and values are lacking. We review the latest literature concerning serum proteomics and their clinical utility regarding the prediction of cerebral vasospasm and other complications of aneurysmal subarachnoid hemorrhage, as well as the clinical outcome. Future prospective studies will allow changing the disease’s course, label patients according to their prognosis to provide earlier and better management and improve outcomes.

subarachnoid hemorrhage
delayed cerebral ischemia
Fig. 1.
Back to top