IMR Press / JIN / Volume 19 / Issue 4 / DOI: 10.31083/j.jin.2020.04.1154
Open Access Original Research
Danggui Sini decoction protects against oxaliplatin-induced peripheral neuropathy in rats
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1 Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, P. R. China
2 Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, 210029, P. R. China
3 Nanjing University of Chinese Medicine, Nanjing, 210023, P. R. China
4 Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210023, P. R. China
5 Haimen City Hospital of Traditional Chinese Medicine, Nantong, 226100, P. R. China
6 81 Hospital of People’s Liberation Army, Nanjing, 210002, P. R. China
*Correspondence: hjg16688@126.com (Jie-Ge Huo)
These authors contributed equally.
J. Integr. Neurosci. 2020, 19(4), 663–671; https://doi.org/10.31083/j.jin.2020.04.1154
Submitted: 17 August 2019 | Revised: 30 October 2019 | Accepted: 4 November 2019 | Published: 30 December 2020
Copyright: © 2020 Ding et al. Published by IMR Press.
This is an open access article under the CC BY 4.0 license ( https://creativecommons.org/licenses/by/4.0/).
Abstract

The effects of Danggui Sini decoction on peripheral neuropathy in oxaliplatin-induced peripheral is established. The results indicated that Danggui Sini decoction treatment significantly reduced the current amplitude of dorsal root ganglia cells undergoing agonists stimuli compared to the model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment significantly inhibited the inflammatory response of dorsal root ganglia cells compared to the model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment significantly enhanced the amounts of Nissl bodies in dorsal root ganglia cells compared to the Model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment improved ultra-microstructures of dorsal root ganglia cells. In conclusion, Danggui Sini decoction protected against neurotoxicity of oxaliplatin-induced peripheral neuropathy in rats by suppressing inflammatory lesions, improving ultra-microstructures, and enhancing amounts of Nissl bodies.

Keywords
Oxaliplatin
peripheral neuropathy
neurotoxicity
electrophysiology
Figures
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