IMR Press / JIN / Volume 18 / Issue 3 / DOI: 10.31083/j.jin.2019.03.1105
Open Access Review
Current anti-Alzheimer’s disease effect of natural products and their principal targets
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1 Department of Neurology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang City, 330006, P. R. China
*Correspondence: (Ye Zhu)
J. Integr. Neurosci. 2019, 18(3), 327–339;
Submitted: 8 July 2019 | Accepted: 3 September 2019 | Published: 30 September 2019
Copyright: © 2019 Zhu et al. Published by IMR press.
This is an open access article under the CC BY 4.0 license

Various bioactive substances isolated from natural products play a pivotal role in the prevention and cure of neurodegenerative diseases, such as Alzheimer’s disease. Currently, there are many theories about the pathogenesis of this disease. In this review we discuss among them, the cholinergic hypotheses, the Aβ toxicity hypothesis, and the tau dysfunction hypothesis. Multiple potential targets are a focus for the development of anti-AD drugs. There is an urgent need to develop more effective therapies to treat and delay the onset of the disease and to find safe and effective drugs. In this review, the recent progress of anti-AD effects and their principal targets are updated.

Alzheimer’s disease
natural products
cholinergic hypotheses
Aβ toxicity
tau hyperphosphorylation
acetylcholinesterase activity
Figure 1.
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