Strength-duration time constants, rheobase currents, and recovery cycles allow the nerve adaptive processes to single or pairs of depolarizing stimuli to be assessed. This study investigates the temperature dependence of these excitability indices of human motor nerve fibers with one of three increasingly-severe type of amyotrophic lateral sclerosis pathology, referred to as ALS1, ALS2, and ALS3. The temperature dependence of the excitability indices was investigated during hypothermia (
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Research article
Theoretical predication of temperature effects at 20
C-42
C on adaptive processes in simulated amyotrophic lateral sclerosis
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1
Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bontchev Str. Bl 21, Sofia 1113, Bulgaria
*Correspondence: dsteph@bio.bas.bg(D. I. Stephanova)
J. Integr. Neurosci. 2018, 17(4), 355–363;
https://doi.org/10.31083/j.jin.2018.04.0417
Submitted: 14 September 2017 | Accepted: 23 February 2018 | Published: 15 November 2018
Copyright: © 2018 The authors. Published by IMR press.
This is an open access article under the CC BY–NC 4.0 license. https://creativecommons.org/licenses/by-nc/4.0/
Abstract
Keywords
Temperature
myelinated axons
ALS
strength-duration time constant
rheobase current
recovery cycle
computational neuroscience
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