Several studies have evaluated the association of Siglec-3(CD33) rs3865444 polymorphism and ATP-binding cassette transporter A7(ABCA7) rs3764650 polymorphism with susceptibility to Alzheimer’s disease. However, these studies have yielded contradictory results. Therefore, to resolve this issue, a meta-analysis was undertaken to examine 12 previously published studies. The pooled effect of CD33 rs3865444 showed no significant relationship with susceptibility to Alzheimer’s disease under various genetic models. The pooled effect of ABCA7 rs3764650 also lacked association with susceptibility to Alzheimer’s disease in the allele model (p = 0.06, OR = 1.06, 95% CI, 1.00-1.13), while significant associations were revealed for the dominant model (p
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Research article
Associations between CD33 rs3865444 and ABCA7 rs3764650 polymorphisms and susceptibility to Alzheimer’s disease
Jing Wang1, Xiangyi Kong2, Lele Cong1, Zhongxin Xu1, Jianshi Du2, Xianling Cong3, Hongyan Sun3, Yanan Xu1, Qing Zhao1,*
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1
Department of Neurology, China-Japan Union Hospital of Jilin University, Chang Chun, 130033, Jilin Province, China
2
Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China
3
Department of Biobank, China-Japan Unoin Hospital, Jilin University, Changchun, 130033, Jilin Province, China
*Correspondence: zhaoqing@jlu.edu.cn(Qing Zhao)
J. Integr. Neurosci. 2018, 17(4), 313–321;
https://doi.org/10.31083/j.jin.2018.04.0408
Submitted: 24 September 2017 | Accepted: 20 November 2017 | Published: 15 November 2018
Copyright: © 2018 The authors. Published by IMR press.
This is an open access article under the CC BY–NC 4.0 license. https://creativecommons.org/licenses/by-nc/4.0/
Abstract
Keywords
Alzheimer’s disease
single nucleotide polymorphisms
CD33 rs3865444
ABCA7 rs3764650
meta-analysis
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