IMR Press / JIN / Volume 17 / Issue 2 / DOI: 10.31083/JIN-170050
Open Access Brief Report
Gsk-3β aggravates depression symptoms in a chronic stress mouse model
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1 Department of Anesthesiology, People's Hospital of Pingxiang City, Jiangxi province, Pingxiang, 337000, P.R. China
2 Department of Rehabilitation Medicine, Shangluo Central Hospital, Shangluo, Shanxi, 726000, P.R. China
*Correspondence: (Hong-bin Wang)
J. Integr. Neurosci. 2018, 17(2), 169–176;
Submitted: 27 May 2017 | Accepted: 5 September 2017 | Published: 15 May 2018

Depression caused by genetic and environmental factors is acomplicated disease. Here, it is demonstrated that glycogen synthase kinase-3$\beta$ is highly expressed and phosphorylated in the brain of a chronic stress mouse. Inhibition of glycogen synthase kinase-3$\beta$ leads to decreased depression-like symptoms which manifest in open-field test, tail-suspension test, forced-swim test, and a novelty suppressed feeding test. It was also found that $\beta$-catenin is attenuated, and its target genes Cyclin D1 and c-Myc are down-regulated. Glycogen synthase kinase-3$\beta$ was also found to inhibit Erk-Creb-BDNF signaling. These results show that glycogen synthase kinase-3$\beta$ may promote the progression of depression. Therefore, targeting glycogen synthase kinase-3$\beta$ may be an effective therapeutic strategy.

Gsk-3$ \beta $
chronic stress mouse model
behavioral testing
Wnt pathway
BDNF pathway
Fig. 1.
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