IMR Press / FBS / Volume 9 / Issue 3 / DOI: 10.2741/S494

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Fertilization failure and gamete health: Is there a link?

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1 Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi, Uttar Pradesh, India

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2017, 9(3), 395–419;
Published: 1 June 2017
(This article belongs to the Special Issue Reproductive biomedicine: from basics to translational outcome)

Fertilization is a hallmark event of sexual reproduction marked by the fusion of male and female gamete to form zygote. It is a highly complex, yet a robust process that is intricately regulated by various signalling molecules. A healthy fertilization is determined by the quality of zygote which is contingent on the health of egg and sperm. The relationship between infertility and gametic health can be reciprocal. On one hand gametogenesis has to be dynamic and unremitting to sustain the reproductive health, while on the other hand it has to be error free for proper embryonic development. Complex cellular interactions make gametogenesis highly vulnerable to extrinsic as well as intrinsic intrusions. Molecular disparities during these phases may result in complete fertilization failure. Present review provides an overview of the regulation of gametogenesis, determinants of healthy gamete, players at fertilization window and what may go wrong during the development of zygote to embryo leading to implantation failure. We have outlined different ‘windows’ of vulnerability during gametogenesis supported by evidences affecting the fertility potential of both the partners.

Gamete Quality
Environmental Interventions
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