IMR Press / FBS / Volume 9 / Issue 1 / DOI: 10.2741/S482

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Enhanced periodontal regeneration using collagen, stem cells or growth factors

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1 Department of Operative Dentistry and Periodontology, University of Rostock, Rostock, Germany
2 Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University of Rostock, Rostock, Germany
3 Institute for Experimental Surgery, University of Rostock, Rostock, Germany

*Author to whom correspondence should be addressed.

Front. Biosci. (Schol Ed) 2017, 9(1), 180–193;
Published: 1 January 2017

The regeneration of periodontal tissues still remains a challenge in periodontology. The aim of the present study was to examine the regenerative potential of a) different collagen support versus blank, b) different collagen support +/-a growth factor cocktail (GF) and c) a collagen powder versus collagen powder + periodontal ligament stem cells (PDLSCs) comparatively in a large animal model. The stem cells (SC) were isolated from extracted teeth of 15 adult miniature pigs. Atotal of 60 class II furcation defects were treated with the materials named above. Concluding, a histological evaluation followed. Asignificant increase in regeneration was observed in all treatment groups. The new attachment formation reached a maximum of 77 percent. In the control group a new attachment formation of 13 percent was observed. The study shows that all implanted materials improved periodontal regeneration, though there were no significant differences between the experimental groups. Within the limitations of this study, it can be assumed that the lack of significant differences is due to the complexity of the clinical setting.

Periodontal Regeneration
Stem Cells
Growth Factors
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