IMR Press / FBS / Volume 9 / Issue 1 / DOI: 10.2741/S469

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Telomere protein complexes and their role in lymphoid malignancies

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1 Laboratorio de Genetica de Neoplasias Linfoides, Instituto de Medicina Experimental, CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

*Author to whom correspondence should be addressed.

Academic Editor: Alejandro Bolzan

Front. Biosci. (Schol Ed) 2017, 9(1), 17–30; https://doi.org/10.2741/S469
Published: 1 January 2017
(This article belongs to the Special Issue Telomeres and telomerase in genome instability)
Abstract

Telomeres are highly regulated and dynamic complexes that protect the genomic DNA and prevent the end of linear chromosomes from being misrecognized as a broken DNA. Due to the end replication problem, telomeres of somatic cells shorten with each cell division, inducing cell senescence. Telomerase is a reverse transcriptase capable of compensating telomere attrition by adding telomere repeats to the ends of chromosomes. Human telomeres are associated with the shelterin complex which consists of six telomere-associated proteins that specifically bind to telomeric DNA. Alterations or removal of individual shelterin components would lead to telomere uncapping and telomere dysfunction, resulting in cellular senescence and transformation to a malignant state. Another complex of multifunctional proteins, named non-shelterin complex, is thought to prevent telomere degradation and facilitate telomerase-based telomere elongation. As telomerase is highly expressed in most human tumor cells, it is considered an attractive target for new therapeutic strategies. In this review, we will summarize the characteristics of telomeres and telomerase in lymphoid malignancies and discuss the role of telomere-associated proteins in these entities.

Keywords
Telomere Length
Telomerase
Shelterin
Telomere-associated Proteins
Lymphoid Malignancies
Review
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