IMR Press / FBS / Volume 8 / Issue 2 / DOI: 10.2741/S463

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Chromosome and genetic testing using ChIP assay

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1 Faculty of Allied Health Science, Yamato University, Katayama-cho 2-52-3, Suita, Osaka 564-0082, Japan
2 Department of Cell Biology, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto, Japan 606-8507
3 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
4 Department of Molecular Cellular and Biochemistry, The Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

*Author to whom correspondence should be addressed.

Front. Biosci. (Schol Ed) 2016, 8(2), 298–302;
Published: 1 June 2016

Chromatin immunoprecipitation (ChIP) assay can be used to easily visualize information about proteins, DNA, and RNA on chromosomes and is widely used for analysis of genomes, epigenomes, mRNAs, and non-coding RNAs. The ChIP assay can detect, not only DNA-binding proteins of various organisms, but also the temporal and spatial regulating mechanisms of RNA-binding proteins. Because of these features, demand for ChIP assay is expected to grow. Here, by using yeast and Drosophila as examples, we describe the superiority of the improved ChIP assay that we have developed.

ChIP Assay
Chip Aequence
Histone Modification
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