IMR Press / FBS / Volume 7 / Issue 1 / DOI: 10.2741/S425

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

How fisetin reduces the impact of age and disease on CNS function
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1 The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, CA 92037

*Author to whom correspondence should be addressed.

Academic Editor: George John Kontoghiorghes

Front. Biosci. (Schol Ed) 2015, 7(1), 58–82;
Published: 1 June 2015
(This article belongs to the Special Issue Aging, neuroinflammation and neurodegeneration)

It is becoming increasingly clear that neurological diseases are multi-factorial involving disruptions in multiple cellular systems. Thus, while each disease has its own initiating mechanisms and pathologies, certain common pathways appear to be involved in most, if not all, neurological diseases. Thus, it is unlikely that modulating only a single factor will be effective at either preventing disease development or slowing disease progression. A better approach is to identify small (< 900 daltons) molecules that have multiple biological activities relevant to the maintenance of brain function. We have identified an orally active, novel neuroprotective and cognition-enhancing molecule, the flavonoid fisetin. Fisetin not only has direct antioxidant activity but it can also increase the intracellular levels of glutathione, the major intracellular antioxidant. Fisetin can also activate key neurotrophic factor signaling pathways. In addition, it has anti-inflammatory activity and inhibits the activity of lipoxygenases, thereby reducing the production of pro-inflammatory eicosanoids and their by-products. This wide range of actions suggests that fisetin has the ability to reduce the impact of age-related neurological diseases on brain function.

Oxidative Stress
Neurotrophic Factors
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