STIM1 and Orai in cardiac hypertrophy and vascular proliferative diseases

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Review

Anne-Marie Lompre^1,2,3,*, Ludovic Benard⁴, Youakim Saliba^1,2,3, Fleur Aubart^1,2,3, Jeremy Fauconnier⁵, Jean-Sebastien Hulot^1,2,3,4

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¹ Inserm UMRS 956- Paris, F75013, France

² Universite Pierre et Marie Curie UMRS956, Paris, F75013, France

³ Institute for Cardiac Metabolism and Nutrition-Paris,75013, France

⁴ Cardiovascular Research Institute, Mount Sinai School of Medicine, New York, USA

⁵ Inserm U1046, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F34000, France

*Author to whom correspondence should be addressed.

Academic Editor: Mohamed Trebak

Front. Biosci. (Schol Ed) 2013, 5(2), 766–773; https://doi.org/10.2741/S406

Published: 1 January 2013

(This article belongs to the Special Issue STIM orai calcium channels mechanisms of regulation and role in human disease)

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Abstract

Cardiac hypertrophy and vascular proliferative diseases are associated with major alterations in calcium homeostasis and calcium signaling. The recent discovery of STIM and Orai has generated great enthusiasm concerning the role of these proteins in the cardiovascular system. We will review the major results concerning the existence and the role of these proteins in the cardiovascular system in normal and pathological situations and their implication in cardiovascular remodeling.

Keywords

Cardiac

Smooth Muscle

Vascular

Proliferation

STIM1

Orai

TRPC

Review

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