IMR Press / FBS / Volume 5 / Issue 2 / DOI: 10.2741/S395

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Designing a peptide-based vaccine against Porphyromonas gingivalis

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1 Department of Odontostomatological, Orthodontics and Surgical Disciplines, Second University of Naples SUN, Naples, Italy
2 Department of Biosciences, Biotechnologies and Pharmacological Sciences, University of Bari, Bari, Italy
3 Dental Clinic, University of Bari, Bari, Italy, 4Neuroscience Department, Milano-Bicocca University, Monza, Monza e Brianza, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Darja Kanduc

Front. Biosci. (Schol Ed) 2013, 5(2), 631–637;
Published: 1 January 2013
(This article belongs to the Special Issue Peptides: from basic research to clinical applications)

Using proteome databases and exploiting the concept that a rare sequence is a potential epitope, epitopic sequences derived from Porphyromonas gingivalis fimA type I protein were examined for pentapeptide sequence similarity score to the human proteome. We obtained data showing that most of the linear bacterial determinants are (or are formed by) peptide fragment(s) absent (or rarely found) in the human proteins. These results seem to confirm the hypothesis that low-sequence similarity may contribute to shape the epitope repertoire and provides a potential tool for designing new immunotherapeutic approaches to apply in Porphyromonas gingivalis infected periodontitis.

P. gingivalis
Bacterial versus human peptide overlap
Low-similarity peptides
Peptide vaccine
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