IMR Press / FBS / Volume 5 / Issue 2 / DOI: 10.2741/S392

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Obstructive sleep apnea and heart disease: the biomarkers point of view
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1 Department of Cardiology, Catholic University of Rome, Rome, Italy
2 Department of Pneumology, Catholic University of Rome, Rome, Italy, 3Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2013, 5(2), 588–599;
Published: 1 January 2013
(This article belongs to the Special Issue Biochemical markers in biological fluids)

Obstructive sleep apnea syndrome (OSAS) is a highly prevalent disorder. Important risk factors for this disease are represented by obesity, male gender, smoking, some endocrinological disturbances, alcohol intake, use of benzodiazepines, and craniofacial alterations. It is well known that OSAS is a frequent comorbidity as well as a relevant risk factor for cardiovascular diseases (CVD), especially in patients with hypertension, coronary artery disease (CAD), arrhythmias, and heart failure. Furthermore, therapy with continuous positive airway pressure devices (CPAP) has been shown to significantly reduce the incidence of serious cardiovascular consequences. Interactions between OSAS and the cardiovascular system (CVS) can eventually result mainly in coronary atherosclerosis. These two conditions are connected by a complex biomarkers network. An extensive overview of these pathways could be helpful to better understand the causes of cardiovascular impairment in patients with OSAS.

Obstructive Sleep Apnea
Cardiovascular Disease
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