IMR Press / FBS / Volume 5 / Issue 2 / DOI: 10.2741/S379

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Genomic stability disorders: from budding yeast to humans
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1 St. Vincent’s Institute of Medical Research, Fitzroy, VIC, Australia
2 Department of Medicine (St. Vincent’s Hospital), University of Melbourne, Fitzroy, VIC, Australia

*Author to whom correspondence should be addressed.

Academic Editor: Alan L. Munn

Front. Biosci. (Schol Ed) 2013, 5(2), 396–411;
Published: 1 January 2013
(This article belongs to the Special Issue The yeast model: its contribution to understanding human disease)

Fundamental aspects of eukaryotic molecular and cellular biology are extensively studied in the budding yeast Saccharomyces cerevisiae. Genome maintenance pathways are highly conserved and research into a number of human genetic disorders with increased genome instability and cancer predisposition have benefited greatly from studies in budding yeast. Here, we present some of the examples where yeast research into DNA damage responses and telomere maintenance pathways paved the way to understanding these processes, and their involvement in selected human diseases.

Budding yeast
DNA repair
Genetic Disorders
Human Disease
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