IMR Press / FBS / Volume 5 / Issue 1 / DOI: 10.2741/S367

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Superfamily 1 helicases
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1 DNA-Protein Interactions Unit, School of Biochemistry, Medical Sciences Building, University of Bristol, University Walk, Clifton, Bristol, BS8 1TD, UK
Academic Editor:Piero R. Bianco
Front. Biosci. (Schol Ed) 2013, 5(1), 206–216; https://doi.org/10.2741/S367
Published: 1 January 2013
(This article belongs to the Special Issue DNA motor proteins - biochemical and biophysical studies)
Abstract

Superfamily 1 helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along, and concomitant unwinding of, DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and, accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination and repair as well as many aspects of RNA metabolism. This review discusses our current understanding of the structure, function and mechanism of Superfamily 1 helicases.


Keywords
Superfamily I Helicase
Helicase
Translocase
Motor
Repair
Recombination
Replication
Review
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