IMR Press / FBS / Volume 4 / Issue 4 / DOI: 10.2741/S350

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism
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1 Medical center for respiratory disease, Nishinihon Hospital, 3-20-1, Hattanda, Kumamoto, 861-8034, Japan
2 Laboratory of Cell and Gene Therapy, Institute for Advanced Medical Sciences, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501 Japan
3 Second Department of Surgery, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan
4 Global COE, Nagoya University School of Medicine, 65, Tsurumai-cho, Showaku, Nagoya, Aichi, 466-8550, Japan
5 Department of Thoracic Surgery, Fukuoka-Wajiro Hospital, 2-2-75, Wajirogaoka, Higashiku, Fukuoka, 811-0213, Japan
6 Department of Chest Surgery, Iizuka Hospital, 3-83, Yoshio-machi, Iizuka, 820-8505, Japan
7 Department of Thoracic Surgery, Shin-Kokura Hospital, Federation of National Public Service Personnel Mutual Aid Associations, 1-3-1, Kanada, Kokurakita-ku, Kitakyushu, 803-8505, Japan
8 Department of Gastroenterology and GI Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan
9 Department of Gastroenterology and Hepatology, Graduate School of Medicine, 54, Shougoin Kawahara-cho, Sakyou-ku, Kyoto University, Kyoto, 606-8507, Japan
10 Department of Environmental Health, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan

*Author to whom correspondence should be addressed.

Academic Editor: Norio Kagawa

Front. Biosci. (Schol Ed) 2012, 4(4), 1539–1546;
Published: 1 June 2012
(This article belongs to the Special Issue Gene regulation and structure-function of P450 Cold stress response)

The occurrence of lung cancer is associated with smoking, which exposes smokers to a series of carcinogenic chemicals. CYP (cytochrome P450) usually metabolizes carcinogens to their inactive derivatives, but occasionally convert the chemicals to more potent carcinogens. In addition to the metabolism of carcinogenic compounds, CYP also participates in the activation and/or inactivation of anti-carcinogenic agents, suggesting that the local CYP expression in lung cancer and surrounding tissues could be an important determinant of efficacy of anticancer drugs. Furthermore, CYP19 (aromatase), estrogen synthase P450, expressed in more than 80% of non-small cell lung cancers. It suggests an association between estrogens and cancer development, which makes aromatase an attractive therapeutic target for the treatment of lung cancer. 1α,25-Dihydroxyvitamin D3 has an inhibitory effect on the proliferation of cancer tissues, and is converted to its inactive 24-hydroxylated derivatives by CYP24, which is frequently expressed in lung cancer tissues. Therefore, understanding the CYP expression in tumor tissues is important in developing better therapies for lung cancer, and may lead us to standardized, "tailor-made" therapies for individuals.

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