IMR Press / FBS / Volume 4 / Issue 3 / DOI: 10.2741/S315

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Endogenous anticancer mechanisms (EACMs)
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1 Department of Biophysics and Center of Biotechnology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

*Author to whom correspondence should be addressed.

Academic Editor: Guido Lenz

Front. Biosci. (Schol Ed) 2012, 4(3), 1017–1030;
Published: 1 January 2012
(This article belongs to the Special Issue Endogenous anticancer mechanisms)

Cells capable of starting the track towards cancer are probably abundant in an organism, but the likelihood of any of these cells to evolve to a deadly disease is very low. This occurs in part due to several safekeeping mechanisms shaped by evolution to detect and eliminate potential cancer-forming cells, which will be defined here as endogenous anticancer mechanisms (EACMs). Virtually any cellular process has safekeeping mechanisms that detect and correct mishaps that could evolve into potentially harmful cellular behavior, but some aspects of these mechanisms seem to have been selected by evolution to protect organisms against cancer. The mechanisms that will be discussed here and in the reviews of this series are: cell senescence, DNA repair, cell cycle control, apoptosis, autophagy, block of the invasion and metastasis cascade, block of cell reprogramming and immune surveillance. Here I will present the basic features and the importance of each EACM and review the involvement of these processes in preventing cancer growth together with their importance in cancer prevention and therapeutics.

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