IMR Press / FBS / Volume 4 / Issue 3 / DOI: 10.2741/S311

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Hypothalamic Akt/PKB signaling in regulation of food intake
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1 Department of Pharmacology, Korea University College of Medicine, Seoul, Republic of Korea
2 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA
3 Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA

*Author to whom correspondence should be addressed.

Academic Editor: Jongsun Park

Front. Biosci. (Schol Ed) 2012, 4(3), 953–966;
Published: 1 January 2012
(This article belongs to the Special Issue Signaling in cancer and disease)

Recent tremendous advances in our understanding of the regulation of food intake are expected to contribute to the treatment of obesity in the near future. The hypothalamus is a center for regulation of food intake and NPY/AgRP and POMC neurons are key regulators of food intake in the arcuate nucleus. The level of energy in the body is monitored by energy sensors in the hypothalamus. A variety of signals originating from peripheral organs to sense the status of energy converge on the hypothalamus and diverse neurons in the hypothalamus are involved in determining the output of signal to regulate food intake. Therefore, it is important to understand the signals and energy sensors in the hypothalamus. In this review, we describe the potential role of Akt/PKB signaling as an energy sensor that regulates food intake.

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