IMR Press / FBS / Volume 4 / Issue 2 / DOI: 10.2741/S295

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The multiple roles of tissue factor in wound healing
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1 Pathology and Laboratory Medicine Service, Durham VA Medical Center, Durham, NC
2 Division of Hematology/Oncology, University of North Carolina, Chapel Hill, NC

*Author to whom correspondence should be addressed.

Academic Editor: L. Vijaya Mohan Rao

Front. Biosci. (Schol Ed) 2012, 4(2), 713–721;
Published: 1 January 2012

The procoagulant role of tissue factor (TF) is well recognized. The ability to form a hemostatic clot is essential to normal healing of an injury. However, TF also has additional activities as a regulator of cellular processes. Both by production of coagulant molecules that also have cytokine and growth factor-like activities, and by directly mediating cell signaling events, TF has the potential to influence the course and tempo of healing. The literature in this are remains somewhat sparse, but suggests that modulation of TF expression plays a role in modulating the host response to injury.

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