IMR Press / FBS / Volume 3 / Issue 4 / DOI: 10.2741/242

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Immunologic mapping of glycomes: implications for cancer diagnosis and therapy
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1 Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77054, USA
2 Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
3 Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
4 Department of Biochemistry, The Ohio State University, Columbus, OH 43210
5 Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, University of Gothenburg, P.O. Box 440, S-40530 Göteborg, Sweden
6 Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968
7 Institute of Biological and Medical Sciences, Medical College, Soochow University, Suzhou 215123, China
8 School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212001, China
9 Institute of Human Virology and Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, MA 21201
10 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
11 Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030
12 Department of Chemistry, University of Texas at El Paso, El Paso, TX 79968

*Author to whom correspondence should be addressed.

Academic Editor: Hafiz Ahmed

Front. Biosci. (Schol Ed) 2011, 3(4), 1520–1532;
Published: 1 June 2011
(This article belongs to the Special Issue Glycobiology of cancer)

Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

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