IMR Press / FBS / Volume 3 / Issue 4 / DOI: 10.2741/239

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Cancer stem cells: perspectives of new therapeutical approaches for breast cancer
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1 Department of Internal Medicine, University of Pisa, Italy
2 Laboratory of Experimental Surgery, Rizzoli Orthopaedic Institute, Bologna, Italy
3 Department of Reproduction and Ageing, University of Pisa, Italy
4 Department of Surgery, University of Pisa, Italy

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2011, 3(4), 1486–1499;
Published: 1 June 2011

Currently stem cells are hypothesized to play a central role in the origin, spread and resistance to treatment of breast cancer. Common anticancer therapy is effective but transient, with tumor relapse and metastatic disease often occurring. For therapy to be more effective, debulking of differentiated tumors must occur followed by targeting of the remaining surviving often quiescent tumor stem cells. New therapeutics aimed at cancer stem cells are achieved through non immunological and immunological methods. The former include elective ABC drug transporters or the heat shock protein 90 inhibition, targeting the self-renewal signalling pathways or the EMT program, differentiation therapy, or other interventions to eliminate BrCSCs. The latter include targeting specific antigens expressed on BrCSCs, dendritic cells (DCs) based vaccination and blockers of the extrinsic signals at CSC niche. Here all these novel approaches related to breast cancer stem cells are described.

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