IMR Press / FBS / Volume 3 / Issue 4 / DOI: 10.2741/233

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cancer immunology and colorectal cancer recurrence
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1 Laboratory of Natural Cell Immunity, Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
2 Laboratory of Tumor Biology, Department of Animal Embryology and Differentiation of Cells and Tissues, Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, v.v.i., Libechov, Czech Republic

*Author to whom correspondence should be addressed.

Academic Editor: Arpad Barabas

Front. Biosci. (Schol Ed) 2011, 3(4), 1421–1431; https://doi.org/10.2741/233
Published: 1 June 2011
(This article belongs to the Special Issue Autoimmune diseases: their etiology, pathogenesis and treatment)
Abstract

The recurrence of a cancer – local or distant (metastasis) – is manifested by the persistence of cancer cells in the organism after the ablation of the primary lesion, an ineffective anticancer immune response, and by the activity of biological/immunological factors that can stimulate and sustain its development. This review focuses on colorectal carcinoma and discusses some aspects of cancer immunology regarding cancer development and its recurrence. It is addressed also to the clinician to provide new insights helpful for designing better therapeutic strategies and patient's follow up. Therapeutic approaches used during and after surgical treatments, found capable of modulating immunity (differently affecting disease outcome), will also be described.

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