IMR Press / FBS / Volume 3 / Issue 3 / DOI: 10.2741/219

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Nitric oxide and thermogenesis - challenge in molecular cell physiology

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1 Department of Physiology, Institute for Biological Research, “Sinisa Stankovic”, University of Belgrade, Serbia
2 Institute of Zoology, Faculty of Biology, University of Belgrade, Serbia

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2011, 3(3), 1180–1195;
Published: 1 June 2011

Only recently we can link thermogenesis, mitochondria, nitric oxide, and redox regulation in biochemical terms. Currently, we are discussing these processes from the aspect of fundamental principles of molecular physiology. Thus, the present article highlights both cell physiology and the principles of the maintenance of energy homeostasis in organisms. Energy homeostasis means much more than simple combustion; adipose tissues at this point of evolution development are related to a broad spectrum of metabolic disturbances and all aspects of cellular remodeling (i.e. structural, metabolic and endocrine changes). Therefore, this paper addresses not only thermogenesis but also energy homeostasis, oxidative phosphorylation and ATP production, proliferation and differentiation of brown adipocytes, their life and death, mitochondriogenesis and angiogenesis. These processes will be united by molecular players of oxidation/reduction reactions, thus creating the principles based on the redox regulation.

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