IMR Press / FBS / Volume 3 / Issue 3 / DOI: 10.2741/210

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The function of histamine receptor H4R in the brain revealed by interaction partners
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1 Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, and CIBER de Enfermedades Raras (CIBERER), Valencia, Spain

*Author to whom correspondence should be addressed.

Academic Editor: Ekaterini Tiligada

Front. Biosci. (Schol Ed) 2011, 3(3), 1058–1066;
Published: 1 June 2011
(This article belongs to the Special Issue Histamine revisited: the H4 receptor in health and disease)

The histamine H4 receptor is mainly expressed in haematopoietic cells, hence is linked to inflammatory and immune system conditions. It has been recently discovered that the receptor is expressed also in the mammalian central nervous system (CNS), but its role in the brain remains unclear. We address the potential functions of the histamine H4 receptor in the human brain using a 'guilty by association' logic, by close examination of protein-protein functional associations networks in the human proteome.

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