IMR Press / FBS / Volume 3 / Issue 3 / DOI: 10.2741/206

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Neural regulation of bone, marrow, and the microenvironment
Show Less
1 Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
2 Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239

*Author to whom correspondence should be addressed.

Academic Editor: Sophia Khaldoyanidi

Front. Biosci. (Schol Ed) 2011, 3(3), 1021–1031;
Published: 1 June 2011
(This article belongs to the Special Issue Stem cell microenvironment)

Bone marrow niches are specialized microenvironments comprising a heterogeneous population of cells that support and regulate hematopoietic stem and progenitor cells. Considerable advances made in the field of hematopoiesis reveal a cross talk between cells, cytokines and neurotransmitters of the hematopoietic, immune and skeletal systems. Dynamic modulation and regulation of stem cells and their niches in response to internal and external stimuli are essential for homeostasis, host defense and repair. This review presents evidence to substantiate stem cell regulation via the "brain-bone-blood triad" beginning at the embryonic stage and continuing to adulthood.

Back to top