IMR Press / FBS / Volume 3 / Issue 3 / DOI: 10.2741/195

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Stem cells cardiac differentiation in 3D systems
Show Less
1 University Campus Bio-Medico of Rome, Department of Cardiovascular Science, Unit of Cardiovascular Surgery, Via Alvaro del Portillo 200, 00128 Rome, Italy
2 University Campus Bio-Medico of Rome, Tissue Engineering Laboratory, Via Alvaro del Portillo 21, 00128 Rome, Italy
3 Georges Pompidou European Hospital, 20 rue Leblanc, 75015 Paris, France
4 University Hospital Valdecilla, Unit of Cardiovascular Surgery, Avenida Valdecilla s/n, 39008 Santander, Spain

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2011, 3(3), 901–918;
Published: 1 June 2011

Cardiac regeneration requires a complex cascade of events. Stem cell therapy and tissue engineering are newly emerging tools with promising potential for recover or replace of damaged cardiac tissue. There are many factors, most of them still no clarified, that limit the effectiveness of these treatments and their translation to the clinic. Cells should graft, survive and functionally integrate to the target organ in order to have a chance to restore its function. As in original tissues, a complex and well defined set of signals, many of them coming from the extracellular matrix, is required for normal cell physiology. Biomaterials science gives us important tools to build this extracellular matrix. Functionalized 3D systems can provide the correct environment and act as a delivery system for genes or gene products, guiding the therapeutic cells to the functional phenotype.

Back to top