IMR Press / FBS / Volume 3 / Issue 2 / DOI: 10.2741/S182

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Targeted antioxidant therapies in hyperglycemia-mediated endothelial dysfunction
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1 Oxidative Stress Laboratory, BakerIDI Heart and Diabetes Institute, Melbourne, Australia
2 Diabetic Complications Division, BakerIDI Heart and Diabetes Institute, Melbourne, Australia

*Author to whom correspondence should be addressed.

Academic Editors: Karen Andrews, Jaye Dusting

Front. Biosci. (Schol Ed) 2011, 3(2), 709–729;
Published: 1 January 2011
(This article belongs to the Special Issue The endothelium in cardiovascular disease)

Although intensive glycaemic and blood pressure control have reduced the risks of micro- and macrovascular complications, diabetes remains a major cause of cardiovascular events, end-stage renal failure, blindness and neuropathy. It is therefore imperative to understand the underlying mechanisms and to establish effective treatments to prevent, retard or reverse diabetic complications. One area of increased focus is the diabetic vascular endothelium. Hyperglycaemia triggers a cascade of events, not least an increase in reactive oxygen species (ROS) leading to enhanced oxidative stress, with its negative impact on endothelial function. In this review, we explore a unifying hypothesis that increased glucose-mediated ROS leads to endothelial dysfunction as the underpinning causative event triggering accelerated micro- and macrovascular complications. In particular, the consequences of deficiencies in the antioxidant enzyme, glutathione peroxidase, on endothelial dysfunction as a trigger of diabetic micro- and macrovascular complications, will be reviewed. Furthermore, novel antioxidant therapies will be highlighted. Specifically, use of Gpx1-mimetics holds promise as a targeted antioxidant approach and an alternative adjunct therapy to reduce diabetic complications.

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