IMR Press / FBS / Volume 3 / Issue 2 / DOI: 10.2741/S172

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Epileptiform activity in the limbic system
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1 Federal University of Pampa at Itaqui, Itaqui 97650-000, RS, Brazil
2 Department of Biological Sciences at the University of Texas at Brownsville and Center for Biomedical Studies, 80 Fort Brown, Brownsville, Texas 78520, USA
3 Department of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil
4 Laboratory of Experimental Neurology, Department of Neurology and Neurosurgery, Federal University of Sao Paulo, São Paulo 04023-900, SP, Brazil

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2011, 3(2), 565–593;
Published: 1 January 2011

Mesial temporal lobe epilepsy (MTLE) is a common neurological disorder characterized by hyperexcitability of limbic structures. Studies in epileptic patients and animal models of MTLE indicate that epileptiform activity arise primarily from limbic areas (e.g. hippocampus) with secondary propagation to cortical areas. A wealth of evidence indicates that epileptiform activity is associated with complex patterns in the expression and function of ion channels, receptors and transporters. Accordingly, several studies portrait MTLE as a post-transcriptional acquired channelopathy. The present review describes the most common features of epileptiform activity emerging from animal models of limbic epileptogenesis and critically discusses the supporting evidence that MTLE is a complex acquired channelopathy.

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