IMR Press / FBS / Volume 3 / Issue 1 / DOI: 10.2741/S145

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Calcium fructoborate: plant-based dietary boron as potential medicine for cancer therapy
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1 University of Craiova, Biochemistry Department, A.I.Cuza, street, no.13, Craiova, Romania, East Europe

*Author to whom correspondence should be addressed.

Academic Editor: Mukesh Agarwal

Front. Biosci. (Schol Ed) 2011, 3(1), 205–215;
Published: 1 January 2011
(This article belongs to the Special Issue Novel strategies for detection, prevention and treatment of cancer)

It was predicted that more B-containing molecules will be discovered that will prove useful in applications involving cell surface signaling, but insufficient progress was made in this general direction. The main objective of this review is to reveal other promising research directions for B-chemoprevention and chemotherapy using Calcium Fructoborate (CF). Targets include breast cancer, prostate cancer, lung cancer and cervical cancer. CF has been identified as Ca ((C6H10O6)2B)24H2O and is a natural product from plants (can be produced by chemical synthesis as well), and is efficient in the prevention and treatments (as adjuvant) of osteoporosis and osteoarthritis. CF showed inhibitory effects on MDA-MB-231 breast cancer cells as well, and enters the cell (most likely) by a co-transport mechanism via a sugar transporter. Inside cells CF acts as an antioxidant and induces the overexpression of apoptosis-related proteins and eventually apoptosis.

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