IMR Press / FBS / Volume 3 / Issue 1 / DOI: 10.2741/S135

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Protein kinase B/Akt regulation in diabetic kidney disease
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1 School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Ireland
2 Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, Northern Ireland, UK

*Author to whom correspondence should be addressed.

Academic Editor: Jongsun Park

Front. Biosci. (Schol Ed) 2011, 3(1), 98–104; https://doi.org/10.2741/S135
Published: 1 January 2011
(This article belongs to the Special Issue Signaling in cancer and disease)
Abstract

Many reviews have been written on protein kinase B/Akt focusing on its history dating back from the isolation of the Akt8 transforming murine leukemia virus by Staal in 1977, to the co-discovery of the Akt1 gene by the three groups in 1991 (reviewed in 7). There are currently over 22,000 publications in the PubMed database with "Akt" as a keyword - these publications describe a wealth of diverse data on the physiological functions of Akt isoforms. Many of these publications describe roles of Akt ranging from its requirement for cellular processes such as glucose uptake, cell survival and angiogenesis to roles in diseases such as cancer and ischaemia (22). This review will focus on the evidence for Akt signaling in different kidney cells during diabetes, or diabetic nephropathy (DN).

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