IMR Press / FBS / Volume 2 / Issue 2 / DOI: 10.2741/S95

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Novel aspects for the application of Curcumin in chemoprevention of various cancers
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1 Department of Clinical Chemistry and Clinical Biochemistry, Ludwig-Maximilians University Munich, München, Germany
2 Functional Genomics, National Research Cancer Institute, Genoa, Italy
3 Institute of Pathology, Academic Clinic Munich-Bogenhausen, Munich, Germany

*Author to whom correspondence should be addressed.

Academic Editor: Sanjay K. Srivastava

Front. Biosci. (Schol Ed) 2010, 2(2), 697–717;
Published: 1 January 2010
(This article belongs to the Special Issue NF-kB: a potential target for cancer)

Chemoprevention of malignant tumor growth is a novel and potentially powerful approach for tumor therapy. Recent in vitro and in vivo investigations provide increasing evidence that naturally occurring substances may exhibit significant chemopreventive activities. To this regard, the spice Curcumin, widely used in Indian cuisine, has been identified to show considerable anti-tumor effects. Most interestingly, numerous studies have not shown toxic side effects of this substance. Curcumin induces tumor cell apoptosis along with a reduction of tumor cell invasion and metastasis. Recent molecular studies provide evidence that Curcumin acts via a control of the NFkappaB pathway exerting most of the various modulating and moderating effects on malignant cells. Along with these in vitro studies, ex vivo and first clinical investigations confirm the anti-tumor effects of Curcumin, either as an isolated chemoprevention substance or in combination with chemotherapeutic agents as supportive measure reducing pharmaceutical resistance of tumor cells to certain chemotherapeutics. Despite our increasing knowledge on this interesting substance there still remain many unknown effects that deserve intense investigation.

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