IMR Press / FBS / Volume 2 / Issue 2 / DOI: 10.2741/S81

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Chemoattractants and receptors in Alzheimer's disease
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1 Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
2 Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA

*Author to whom correspondence should be addressed.

Academic Editor: Yingying Le

Front. Biosci. (Schol Ed) 2010, 2(2), 504–514;
Published: 1 January 2010
(This article belongs to the Special Issue Pleiotropic roles of chemotactic factors and their receptors)

Chemoattractants, including classical chemoattractants and chemokines, are mediators of leukocyte trafficking in physiological immunosurveillance as well as recruitment of leukocyte to the sites of inflammation and injury. Besides their well-established role in the immune system, recent researches have demonstrated that chemoattractants and their receptors are also involved in brain development and in the maintenance of normal brain homeostasis. Evidence is emerging that chemoattractants and their receptors play important roles in neuroinflammation, neuronal death and hence neurodegenerative diseases. In this review, we summarize recent progress regarding the involvement of chemoattractants and their receptors in Alzheimer's disease and their potential as therapeutic targets.

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