IMR Press / FBS / Volume 2 / Issue 2 / DOI: 10.2741/S76

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury

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1 Department of Pediatrics, Maastricht University Medical Center, School for Oncology and Developmental Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands
2 Child Neurology, Maastricht University Medical Center, in collaboration with the School for Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences Maastricht University, The Netherlands
3 School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University and European Graduate School of Neuroscience (EURON), The Netherlands
4 Department of Obstetrics and Gynecology, Klinikum Osnabrück, Osnabrück, Germany
5 Animal Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands

*Author to whom correspondence should be addressed.

Academic Editor: Diego Gazzolo

Front. Biosci. (Schol Ed) 2010, 2(2), 432–438;
Published: 1 January 2010
(This article belongs to the Special Issue Clinical and biochemical markers and fetal-neonatal development)

We evaluated the impact of chorioamnionitis on the intrapartal EEG delta frequency in the non-anesthetized preterm sheep. 10 mg intra-amniotic LPS or saline were given 2 or 14 days before preterm birth at gestational day 125. Lambs were delivered by Caesarean section under local anesthesia. A 5-minute EEG depicted delta activity and amplitude, and the relationship between EEG delta activity and both the white matter (WM) and cortical microglial activation and apoptosis was analyzed. EEG delta activity was increased significantly in the 14-day LPS preterm fetuses compared to both preterm control and 2-day LPS animals (p less than 0.05). No differences were seen between controls and the 2-day LPS fetuses. A direct association was demonstrated between EEG delta activity and both cortical microglial activation (r = 0,645, p = 0,024) and apoptosis (r = 0,580, p = 0,048), and between delta and WM activated microglia (r = 0,742, p = 0,006) and apoptosis (r = 0,777, p = 0,003). This study is the first to show a relationship between brain dysfunction and chorioamnionitis-related injury at birth.

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