IMR Press / FBS / Volume 2 / Issue 2 / DOI: 10.2741/S75

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Biological and clinical markers in colorectal cancer: state of the art
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1 Department of Surgery, General and Breast Surgery,University Hospital, Catania, Italy
2 Department of Surgery, Transplantation and Advanced Technologie, University Hospital, Catania, Italy; Vascular Surgery and Organ Transplant Unit Catania University Hospital
3 University of Catania, Research Fellow in Surgical Pathology, University Hospital, Catania, Italy
4 University of Maryland, Division of Laparoscopic and Bariatric Surgery, Baltimore, MD, USA
5 University of Catania, Department of Internal Medicine, Garibaldi-Nesima Hospital, Catania, Italy
6 Division of Pathology, National Cancer Institute, Aviano (PN), Italy
7 Department of Anaesthesia and Intensive Care, University Hospital, Catania, Italy
8 Department of Medical Oncology, National Cancer Institute, Aviano (PN), Italy

*Author to whom correspondence should be addressed.

Academic Editor: Giovanni Li Volti

Front. Biosci. (Schol Ed) 2010, 2(2), 422–431;
Published: 1 January 2010
(This article belongs to the Special Issue Biochemical markers in biological fluids)

Colorectal cancer (CRC) is the World's third most common cancer. Its prognosis is closely related to the disease stage at the time of diagnosis. Here we review the role of clinical biomarkers (tissue, serum, and faecal) in the management of CRC. Molecular studies have recently widened the opportunity for testing new possible markers, but actually, only few markers can be recommended for practical use in clinic. In the next future the hope is to have a complete panel of clinical biomarkers to use in every setting of CRC disease, and at the same time: 1) to receive information about prognostic significance by their expression and 2) to be oriented in the choice of the adequate treatment.

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