IMR Press / FBS / Volume 2 / Issue 2 / DOI: 10.2741/S101

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Brain apoptosis and carotid artery reactivity in fetal asphyctic preconditioning
Show Less
1 Departments of Pediatrics-Neonatology, Maastricht University Medical Center, Maastricht, The Netherlands
2 Child Neurology, Maastricht University Medical Center, Maastricht, The Netherlands
3 School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, European Graduate School of Neuroscience (EURON
4 School for Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences Maastricht University, Maastricht, The Netherlands

*Author to whom correspondence should be addressed.

Academic Editor: Yingxian Pan

Front. Biosci. (Schol Ed) 2010, 2(2), 781–790;
Published: 1 January 2010
(This article belongs to the Special Issue regulation and function of opioid receptor genes)

We aimed to develop a model of fetal hypoxia-ischemia (HI) preconditioning that reflects the pathophysiological conditions of perinatal asphyxia more closely than the existing neonatal stroke models. Fetal asphyxia (FA) was induced by clamping the uterine vasculature on embryonic day E17. At birth (P0), severe perinatal asphyxia (SPA) was induced during cesarean section. At P4, carotid arteries were studied in a wire myograph and at P8 brains were analyzed for apoptotic cell death in the prefrontal cortex and striatum. The contraction induced by K+ was significantly reduced in the carotid arteries from the SPA group and endothelium-dependent relaxation (mediated by acetylcholine) was augmented in the FA group. These changes in vascular responsiveness were not present in the animals exposed to both insults (FA + SPA). Additionally, FA+SPA animals showed lower numbers of apoptotic cells compared to SPA animals in both the prefrontal cortex and striatum. Exposure to a global fetal asphyctic insult seems to protect against the vascular alterations and the increase of apoptosis in striatum and prefrontal cortex induced by severe asphyxia at birth.

Back to top