IMR Press / FBS / Volume 2 / Issue 1 / DOI: 10.2741/S68

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Biomarkers in neuroendocrine tumors
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1 Department of Medical Oncology, National Cancer Institute Aviano, Aviano, PN, Italy
2 Department of Surgery, University of Catania, Catania
3 Department of Colorectal Oncology/Medical Oncology, National Cancer Institute, G. Pascale Foundation Naples
4 Division of Pathology, National Cancer Institute Aviano

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2010, 2(1), 332–342;
Published: 1 January 2010
(This article belongs to the Special Issue Biochemical markers in biological fluids)

Here, we review the role of clinical biomarkers (tissue and circulating markers) in the management of neuroendocrine tumors. These tumors may originate in different organs, from cells embriologically different but expressing common phenotypic characteristics, such as the immuno-reactivity for markers of neuro endocrine differentiation (defined as "pan-neuroendocrine"), the capacity to sec rete specific or aspecific peptide and hormones, and the expression of some receptors, that are at the basis of the current diagnostic and therapeutic approach.

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