IMR Press / FBS / Volume 2 / Issue 1 / DOI: 10.2741/S60

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

EMT and TGF-beta in renal fibrosis
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1 First Department of Internal Medicine, Nara Medical University, 840 Shijo, Kashihara, Nara 634-8522, Japan

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2010, 2(1), 229–238;
Published: 1 January 2010

Transforming growth factor-beta1 (TGF-beta1) is a member of TGF-beta superfamily and the principal mediator contributing to the development and progression of renal fibrosis in a variety of disease settings. A critical effect of TGF-beta1 is the induction of epithelial-mesenchymal transition (EMT), which likely explains the continuous replenishment of fibroblasts during the progression of tissue fibrosis. Since we first identified EMT as the origin of fibroblasts in renal fibrosis, the signaling underlying EMT has been intensively studied in the field of nephrology. During the past five years, detailed mechanisms by which TGF-beta1 induces EMT have been clarified, and novel therapeutic approaches targeting TGF-beta1-mediated EMT are now being proposed.

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