IMR Press / FBS / Volume 2 / Issue 1 / DOI: 10.2741/S58

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Enzymes and bioscavengers for prophylaxis and treatment of organophosphate poisoning
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1 University of Massachusetts Medical Center, Worcester, Massachusetts, USA
2 South Asian Clinical Toxicology Research Collaboration (SACTRC), Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka and School of Population and Health, University of Newcastle, Newcastle, New South Wales, Australia
3 Australia National University, Canberra, Australia

*Author to whom correspondence should be addressed.

Academic Editor: Romolo Gaspari

Front. Biosci. (Schol Ed) 2010, 2(1), 209–220; https://doi.org/10.2741/S58
Published: 1 January 2010
(This article belongs to the Special Issue Organophosphate poisoning: integrating basic and clinical science)
Abstract

Organophosphorus (OP) pesticide poisoning causes significant morbidity and mortality, particularly in the developing world, with upwards of 3 million people poisoned each year. Although OP poisoning is not common in developed countries, recently greater attention has been given to these chemicals because of their similarity to chemical warfare agents. Despite the agricultural use of OP pesticides for roughly 60 years, no new therapies have been developed since the 1960s. A promising field of novel antidotes for OP poisoning, OP hydrolases, has recently garnered increased support. These bacterial enzymes have demonstrated tremendous prophylactic and antidotal efficacy against a few different OP classes in animal models. These studies, as well as the limitations and challenges of therapeutic development of these enzymes, are discussed.

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