IMR Press / FBS / Volume 2 / Issue 1 / DOI: 10.2741/S48

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Persistent low-grade inflammation and regular exercise
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1 The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC Copenhagen University Hospital, Rigshospitalet, University of Copenhagen, Faculty of Health Sciences, Denmark

*Author to whom correspondence should be addressed.

Academic Editor: Richard Simpson

Front. Biosci. (Schol Ed) 2010, 2(1), 96–105;
Published: 1 January 2010
(This article belongs to the Special Issue Exercise effects on immunity: cellular and molecular responses)

Persistent low-grade systemic inflammation is a feature of chronic diseases such as cardiovascular disease (CVD), type 2 diabetes and dementia and evidence exists that inflammation is a causal factor in the development of insulin resistance and atherosclerosis. Regular exercise offers protection against all of these diseases and recent evidence suggests that the protective effect of exercise may to some extent be ascribed to an anti-inflammatory effect of regular exercise. Visceral adiposity contributes to systemic inflammation and is independently associated with the occurrence of CVD, type 2 diabetes and dementia. We suggest that the anti-inflammatory effects of exercise may be mediated via a long-term effect of exercise leading to a reduction in visceral fat mass and/or by induction of anti-inflammatory cytokines with each bout of exercise.

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