IMR Press / FBS / Volume 2 / Issue 1 / DOI: 10.2741/S46

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Development of microfluidic-based heterogeneous immunoassays
Show Less
1 Southlake Regional Health Centre, Newmarket, Ontario, Canada
2 Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada
3 Department of Mechanical & Mechatronics Engineering University of Waterloo, Waterloo, Ontario, Canada
4 Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
5 Departments of Paediatrics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2010, 2(1), 73–84;
Published: 1 January 2010

Microfluidic-based heterogeneous immunoassays are reviewed in this article by first introducing the principle of immunoassay, followed by a discussion of microfluidic-based technology. Microfabrication, surface modification, solution dispensing and detection technology are discussed and their applications to biomolecular detection reviewed. In the future, improved manufacturing processes and integrated assay systems in an automatic fashion with a reduced assay time and reagent consumption will allow for the effective detection of biomolecules that are of interest in medical diagnostics, drug discovery and bioterrorism.

Back to top