IMR Press / FBS / Volume 2 / Issue 1 / DOI: 10.2741/S42

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The shady side of sunlight: current understanding of the mechanisms underlying UV-induction of skin cancers
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1 Department of Pthology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
2 Department of ObstetricsGynecology, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2010, 2(1), 11–17;
Published: 1 January 2010

The incidence of skin cancer has been rising at an astonishing rate, particularly that of the deadliest skin cancer, melanoma. While the molecular mechanisms of sunlight ultraviolet radiation (UV)-induced non-melanoma skin cancer (NMSC) have been well documented, there is a major gap in our current knowledge of how UV initiates melanoma. However, the components of the retinoblastoma (Rb) pathway, the p53 and the p16 pathways are considered the major targets of UV-induced NMSC and melanoma, respectively. Our recent study has revealed that these two pathways coordinate the early responses to UV radiation in the skin. Here, we review the value of studies targeting these early events of skin carcinogenesis, with specific focus on the critical role of the components of the Rb pathway.

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